This Microcrystalline Cellulose . The product would later go on to be commercialized under the brand name Avicel by FMC Corporation. {iy7uEijn0y]"s"gbV~p8Q)zN:cyvs]&,kk=6pcA %iBW|2nKa)Jb7` 0
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Avicel Microcrystalline cellulose is composed of insoluble fibre and does not contribute any other material of nutritional importance. Packaging: 34 x 50 kgs fiber drums. Molecular Weight null. ( Of all the different brands and grades of MCC, Avicel PH 101 or Emcocel 50 has been the most widely used. <<
No. Material Safety Data Sheet or SDS for Cellulose microcrystalline 102331 from Merck for download or viewing in the browser. The table below lists the most important chemical identifiers applicable to Avicel Microcrystalline cellulose. /Producer(Sub Systems, Inc.)/CreationDate(D:20211228124915+05'00')/ModDate(D:20211228124915+05'00')/Creator(Sub Systems, Inc.)
No. B;vLZpHU%ChUyD+[ To meet their exacting standards, we deliver a wide choice of relevant solutions that are simultaneously replicable, scalable and high performing. This extends the funcionality of microcrystalline cellulose to meet specific viscosity, gelling, suspension and stabilizing properties ChemPoint is an approved supplier of LATTICE MCC in industrial applications, providing dedicated marketing, sales, order fulfillment, and technical support for customers in the EMEA region, Protect and improve AI potency, entrap oil droplets and improve stability, physical barrier that helps suspend particles and breaks down under shear and reforms quickly under rest. It . Heavy metals, % NMT 0.001 LATTICE Microcrystalline Cellulose by Dupont, is an alpha cellulose obtained from naturally ocurring cellulose found in wood pulp, which is an equal structuring polysacharide that is found on fruits and vegetables. Cellulose microcrystalline. ]c\RbKSTQ C''Q6.6QQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQ p@" Similarly, the European Food Safety Agency has also evaluated Microcrystalline cellulose and established that it is not absorbed systemically and excreted unchanged. F. Lerk, G.K. Bolhuis, A.H. De Boer, Effect of Microcrystalline Cellulose on liquid penetration in and disintegration of directly compressed tablets, Journal of Pharmaceutical Sciences, 68 (1979) 205-211. Avicel Microcrystalline Cellulose is a safe and non-hazardous material that is widely used in pharmaceutical formulations and food products (as a bulking agent and to add crispness). The global Microcrystalline Cellulose (Mcc) market size is projected to reach multi million by 2026, in comparison to 2022, at unexpected CAGR during 2022-2026. Same quality to grades 102/90M, but very low moisture content (< 1.5 %) for processing water-sensitive actives. EMCOCEL 90 M. 130. Enter your [postal] code to see information about local products, representatives and retailers, along with special offers in your area. Millipore. Product Name: MICROCRYSTALLINE CELLULOSE Date/ Revised: 27/November/2012 Page 1 of 4 1. At the same time, its pronounced shear-thinning behavior enables handling of even highly viscous solutions. AVICEL RC 581. Product Name: Microcrystalline Cellulose 1.2. Our customers around the world enjoy the benefits of TEXTURECEL NaCMC in various wound care products, too. It is widely used within the pharmaceutical, food, and cosmetic sectors as a formulation aid. We know that our customers need to provide reliable and consistent products to their patients. Synonyms: Cellulose, Cellulose powder, Cotton linters. stream X`I%&/m{JJt`$@iG#)*eVe]f@{{;N'?\fdlJ!?~|? An internally cross-linked sodium carboxymethyl cellulose (NaCMC), it aids in the disintegration and drug dissolution of pharmaceutical tablets, capsules, and granules. %
( EMCOCEL XLM 90. YUMPU automatically turns print PDFs into web optimized ePapers that Google loves. };khd5x=fr Copyright 2023 by International Flavors & Fragrances Inc. IFF is a Registered Trademark. : 9004-34-6 Date Approved: 01/31/2008 . !,K`I[O@U|$+i 8sB|+"B@'2^7[2XKrd#5b They are soluble in a wide range of organic solvents, beginning with aliphatic alcohols such as ethanol and isopropanol, and are compatible with most other familiar organic solvent chemistries, including ether alcohols, ketones, aromatic hydrocarbons and many more. : 5. In roller compaction, Avicel Microcrystalline cellulose improves compaction during the ribbon phase, enabling a trouble-free process while also preserving the plasticity of the compacts. Innovation is at the heart of IFFs purpose of applying science and creativity to create a better world. MATERIAL SAFETY DATA SHEET. CAS No. Assay: 0.98 Appearance: Off white to slight yellow solid Package: 1L 5L 10L 25L bottle Storage: Stored in shaded, cool and dry places Transportation: Handle with cares to avoid damaging the packages. Foam Booster/Stabilizer; Rheology Modifier; Stabilizer-Emulsion; Suspending Agent . LATTICE Microcrystalline Cellulose has many important uses within the food, pharma, specialty applications and industrial such . }o]X4]. Microcrystalline cellulose (MCC) is the most commonly used spheronizing aid in a formulation undergoing extrusion spheronization. It is an excipient approved for use in pharmaceutical products and is also GRAS listed and accepted for use as a food additive in Europe and the United States and is included in the FDA Inactive Ingredients Database (oral: powders, suspensions, syrups, and tablets; topical & vaginal products). pb7c8BHqCRX_eL +90w~ gk[YBkf9eDNJdNn q^16mi=4Sr0~{lZ>yvMqS'e,MqB?;Oy9s'$8asJgEh0SS>|J58ub^q
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Microcrystalline Cellulose / Avicel PH-102. Material safety data sheet - FMC Corporation. pfTr^i5wOg)y .6
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More sophisticated drug discovery techniques have led to pipeline compounds that require solubility enhancement to be therapeutically effective. Meet our leadership team. 10.1 Future Forecast of the Global Microcrystalline Cellulose Market from 2023-2028 Segment by Region 10.2 Global Microcrystalline Cellulose Production and Growth Rate Forecast by Type (2023-2028 . Created Date: 2/10/2020 8:51:41 PM . pH 6.0 to 8.0 . Doses up to 30 g per day appear to be . Avicel CL-611 Microcrystalline Cellulose and Sodium Carboxymethylcellulose Page 1 of 9. Quick Links. Home. TEXTURECEL NaCMC is applied in oral solids, such as granules and pellets, powders as well as coatings for tablets. More than 65 years later, Avicel continues to command global acceptance, with no signs of its popularity waning. An agricultural sciences company. FMC has deep roots in the food production system worldwide learn more about our latest advances in the future of agriculture. 4 0 obj
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This grade of polymer film remains intact at pH< 6, thus protecting the API in gastric environments. The current product range and recommended usage are summarised below: Microcrystalline Cellulose is currently listed in the United States Pharmacopoeia and National Formulary, the European Pharmacopeia, the Japanese Pharmacopoeia, the British Pharmacopoeia, in addition to the Indian and Chinese Pharmacopeia, to name but a few. Chemical Name Microcrystalline cellulose (INCI Name): MCC, cellulose gel Common Name Avicel PH105 Microcrystalline Cellulose CAS Number 9004-34-6 Impurities and/or Stabilizing Additives No data available Section 4: First Aid Measures General Advice No data available If Inhaled Remove person to fresh air. vdZ@Rgl{eU+7N!3!|hUmW)~}U*7k i@j)q["MEydtP"ftFu]t }JN~A"8lz7#}J.i@
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Avicel RC-591 & CL-611 - Description. %PDF-1.4
Slightly soluble in 5% w/v sodium hydroxide solution; practically insoluble in water, dilute acids, and most organic solvents. Have an order or account question? ( In many applications, one METHOCEL product can perform the job of two, three or even more ingredients saving money and time. SDS - Safety Data Sheet. 6 0 obj
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3Fz. Watch Now. It is insoluble in water, dilute acids, common organic solvents and oils, partially soluble with . Go to Investor Relations. Studies from the World Health Organisation and the European Food Safety Agency have concluded that Microcrystalline cellulose has no safety concerns for the public when used in animal nutrition. "l%I-*j|-)@
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Test Data Available. GENERIC EU MSDS - NO COUNTRY SPECIFIC DATA - NO OEL DATA 1. These, in turn, are assembled into fibrils in the cell wall. %PDF-1.3 Avicel Microcrystalline cellulose occurs as a white, odourless, tasteless, fibrous powder composed of porous particles. It is also inert and biocompatible. Avicel PC 611 (FMC Biopolymer) . AFFINISOL HPMC has been specifically designed for generating solid dispersions via spray-drying (SDD) or hot melt extrusion (HME) in the pharmaceutical industry. Microcrystalline cellulose in certain fiber supplements may cause mild side effects ().These may include gas, bloating and increased stool production.. microcrystalline cellulose and carboxymethylcellulose sodium NF, Ph. Aqueous suspensions of microcrystalline cellulose have . Product and Company Identification Product Name Microcrystalline Cellulose CAS Number 9004-34-6 Parchem - fine & specialty chemicals 415 Huguenot Street New Rochelle, NY 10801 (914) 654-6800 (914) 654-6899 parchem.com info@parchem.com EMERGENCY RESPONSE NUMBER Explore how we work and why we apply science and creativity for a better world to everything we do. When selected in wet granulation, the optimum level of use is between 5 and 20%, although higher levels have been successfully used. However, it yields non-digestible fibre. Find answers in our support articles. All Rights Reserved. Microcrystalline cellulose -The oldest polymer finds new industrial uses,. GRINDSTED Xanthan Gum is a naturally fermented product of carbohydrates and is applied in various liquid, semi-solid and solid pharmaceutical dosage forms. AFFINISOL hydroxypropyl methylcellulose (HPMC) is a water-soluble cellulosic polymer that can help optimize solubility enhancement of poorly soluble drugs by maintaining stable solid dispersions and inhibiting API crystallization. >>
Cellulose, microcrystalline | C14H26O11 | CID 14055602 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological . /MediaBox [0 0 612 792]
Comments: The human studies including the use of radiolabelled microcrystalline cellulose show complete absence of digestion or absorption. Buy Chemicals. Van Veen, G.K. Bolhuis, Y.S. The main source of cellulose is woody plants, since it is the main building block of the cell walls of higher plants. II: effects of changes in the content of Microcrystalline Cellulose, AAPS PharmSci, 2 (2000) 45. PROSOLV SMCC, silicified microcrystalline cellulose, is a unique combination of microcrystalline cellulose (MCC) and colloidal silicon dioxide (CSD).A high functionality and multifunctional excipient, it requires less complex processing, has high inherent functionality, and passes that functionality on to the drug formulation. In the late 1960s, Avicel Microcrystalline cellulose was registered in the supplement to the National Formulary as a pharmaceutical excipient. [FMC Study Number I92-1464]. Remove MATERIAL SAFETY DATA SHEET Avicel PH Microcrystalline Cellulose MSDS Ref. {ddn(Y?I#K-}t|l #:FHF'D)/)"{k\pM
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WQC}>e|Gs_Q'+mB| X{URv/Z'` 4w'8sC~ cON&pIk:F/Q&u~.S{"% pg:lfx -. Alubra sodium stearyl fumarate from IFF Pharma Solutions is a comparatively hydrophilic lubricant widely used in capsule and tablet formulations. Alginate drug delivery harnesses the unique properties of seaweed for premier performance in multiple pharmaceutical and nutraceutical applications; they impart viscosity in solutions and even form a three-dimensional gel in the presence of calcium ions. Chemically, it is an inert substance, is not degraded during digestion and has no appreciable absorption. Microcrystalline cellulose 9004-34-6 232-674-9 Not Listed * Magnesium stearate 557-04- 209-150-3 Not Listed * PDF (2.77 mb) 2021 FMC Sustainability Report. Gloves, eye protection and a dust mask should be used. All rights reserved. CeolusTM UF-702, MSDS No.060EU MATERIAL SAFETY DATA SHEET NTP: Not listed ACGIH: Not listed 12. /Producer(Sub Systems, Inc.)/CreationDate(D:20181207095625+05'00')/ModDate(D:20181207095625+05'00')/Creator(Sub Systems, Inc.)
: 51395-75-6 Date Approved: 01/31/2008 Revision No. JRS Pharma: PROSOLV SMCC 90 LM: Microcrystalline Cellulose, Colloidal Silicon . >z+{!A6wy @nLK3R#hRn sba3;b61V:#Z3X,*?RC!wPmqd7WkA'aZMt6PFV3SEvlY'=p.mn[I{puc\6'ZIyI%rD'zA!"t3I2F ^R;LK,?:&THv*y^K> o0Af?J9J-{s2&cCn)32ADzl%sS5O~J[
Material safety data sheet (MSDS) of the m icrocrystalline cellu lose (MCC) Frijlink, Compaction mechanism and tablet strength of unlubricated and lubricated (silicified) Microcrystalline Cellulose, European journal of Pharmaceutics and Biopharmaceutics, 59 (2005) 133-138. 2021 Annual Report. Micro Crystalline Cellulose. Microcrystalline cellulose (MCC) is one of the most important tableting excipients thanks to its outstanding dry binding properties, enabling the manufacture of tablets by direct compression (DC). There may be more fiber in your food than you realized. <
gV2@o2s&WS@Et%Up:`U '_ h?8qyP=&> GFprm9A!uu1 }&*kQ c^&eX}^K}h9YCb2L(yL):,+g8_u. GRINDSTED Xanthan Gum readily dissolves in water under ambient conditions without the need of special high-shear equipment. Avicel RC-591 offers ideal thixotropic bahavior for stabilizing suspensions while Avicel CL-611 is a stabilizer for reconstitutable or dry suspension formulations. Instead, they obtained a stable colloidal suspension. Document(s): certificate data msds. Ac-Di-Sol Croscarmellose Sodium is one of our flagship offerings for pharmaceutical manufacturers. CAS 9004-34-6, pH 5 - 7.5. Stabilizer composition of co-attrited microcrystalline cellulose and carboxymethylcellulose, method for making, and uses CN103842425B . 1.3. . Quantity: 1 700 kgs. MSDS Ref. These grades have particle sizes ranging from <30 to approximately 200. CAS 9004-34-6. The range of products includes three basic types of carrageenan kappa, iota and lambda from various species of red seaweed. Superior Performance: Provides excellent water uptake and rapid swelling . Eur., JPE . 130. : 1. If breathing is difficult or if . 0.25 - 0.37. gac74
[#B6`Wnw7 They are white to off-white, free-flowing hydrophilic powders supplied in a variety of viscosity grades corresponding to approximate molecular weight, ranging from 100,000 to 7,000,000 daltons. Ui[(lY[|//o)ZmqbQT-Y.M|se[)m?(WRV.W8J/j}9>X.VNsZNOp'^14nuXM%rea5]@ MKnNe /Parent 3 0 R
The METHOCEL Premium family of water-soluble polymers for pharmaceutical applications offers exceptional flexibility and a broad range of properties typically not found in other water-soluble polymers. However, if handling bulk powders, observance of appropriate safeguards is recommended. You have already flagged this document.Thank you, for helping us keep this platform clean.The editors will have a look at it as soon as possible. 51395-75-6 Avicel RC 591. By utilizing proprietary co-processing technologies, Dupont also manufactures LATTICE NTC products. It is highly versatile and is therefore also widely used in topicals and semi-solid & liquid dosage forms, including ointments, creams, gels, pastes, solutions, suspensions, and emulsions. XiDqLN MD'F2`jI7ZWu,JK%5e9~:R>LAm\WyY0lk=ZNP;pZ23)P0GG~%e[ d8GIXRo&. Non-woody sources are also viable sources of cellulose, although only woody plants and cotton are the main sources for microcrystalline cellulose used as a pharmaceutical excipient. Fmc Corporation: Ultra-fine microcrystalline cellulose compositions and process . This paper is based on a study of the interactions that take place during the process of hydrogel formation, break down, and recovery. High performance lubricant that brings more to the tablet. >>
Aquacoat ECD is an aqueous dispersion of ethylcellulose used for sustained release barrier or slow release pharmaceutical coating, moisture barrier and taste masking applications for tablet and multi-particulate dosage forms. iQuLyI4D@yq#u0dZt=0?QUz{K6by_C"vW~Nj$bo? The fumarate moiety of Alubra increases its melting temperature, which allows for greater functionality at high press speeds while the stearate chain maintains the lubricity of the compound and supports low ejection forces. J]3yzZ2Z$mZ7o%-Xyq'()V9KX0gk~AA
Cu:3(]N"AQdUt~h|P MATERIAL SAFETY DATA SHEET Lattice NT Microcrystalline Cellulose MSDS Ref. Cellulose microcrystalline MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents. Are you looking for information about products and services by region? Safety Data Sheet for Cellulose microcrystalline 102331. Unique functionality for a broad range of pharmaceutical applications. Various Gelcarin and Viscarin carrageenan grades are used by the pharmaceutical industry to achieve specific gelling for controlled drug release, thickening, and stabilizing properties desired in various formulations. In summary, Avicel microcrystalline cellulose is virtually inert, its energy content is very low or zero and it is not absorbed. Manufacturer: FMC BioPolymer. : 9 This document has been prepared to meet the requirements of the U.S. OSHA Hazard Communication . Pharmacel 112 is a directly compressible microcrystalline cellulose grade with a low moisture content (LOD Max. It is . Microcrystalline cellulose (MCC) for industrial purposes is usually obtained from wood pulp and purified cotton linters. Alginates from IFF are an excellent choice for consistent performance in a variety of applications. Microcrystalline cellulose has excellent compressibility properties and is widely used in solid forms such as tablets that are hard, but can dissolve quickly, and this has increased its demand in . Avicel Microcrystalline cellulose was discovered in 1955 by a team at FMC Corporation, led by the legendary Canadian-born chemist, Orlando Aloysius Battista, which he initially named mechanically disintegrated D.P cellulose. Avicel Microcrystalline cellulose also serves as a moisture adsorbent and as a general-purpose formulation improver. Alginates also function as actives in some anti-reflux products. The highly reactive amorphous regions selectively hydrolyze, releasing the crystallites, which are subsequently mechanically dispersed. Manufactured by: China . 1.5% w/w), especially designed for formulating active pharmaceutical ingredients (APIs) with a high sensitivity for moisture. Currently, it is marketed both directly and indirectly (through distributors) depending on the country in question. The substance identifiers displayed in the InfoCard are the best available substance name, EC number, CAS number and/or the molecular and structural formulas. The representative usage of Avicel PH-101 and Avicel PH-102 Microcrystalline cellulose in wet granulation and direct compression is shown in the following two examples. The polymers added organosolubility further creates advantages for employing HPMC in solvent spray-drying applications. msdsinfo@fmc.com (Email - General Information) FMC Europe NV Avenue Mounier 83 1200 Brussels, Belgium 353 21 435 4133 (General Information - Cork, . The figure below illustrates the structural organisation of cellulose within plants. Microcrystalline Cellulose / Avicel PH-102. Your file is uploaded and ready to be published. (1962). undefined. No. : 9004-34-6 1.2 Relevant identified uses of the substance or mixture and uses advised against Revision No. Medium size standard MCC grade, suited for the majority of directly compressible actives. Pharmacel 112 can be used in a wide range of oral solid dosage (OSD) forms as binder, compressing agent . Microcrystalline Cellulose E460 MSDS 1. Looking for FMC'searnings news? LATTICE Microcrystalline Cellulose has many important uses within the food, pharma, specialty applications and industrial such as non-stick coatings, insulation of wiring, crop protection and paints,coats and inks. 1 0 obj
Patel, F. Podczeck, Investigation of the effect of type and source of Microcrystalline Cellulose on capsule filling, International Journal of Pharmaceutics, 128 (1996) 123-127. %PDF-1.4
Avicel PH-200 microcrystalline cellulose NF, Ph. Description:Chemical PropertiesMicrocrystalline cellulose is a purified, partially depolymerized cellulose that occurs as a white, odorless, tasteless, crystalline powder composed of porous particles. No: 9004-34-6-5 Version: Global Date Approved: 10/16/1998 . Magazine: Material safety data sheet - FMC Corporation. It is, however, a good source of fibre. Microcrystalline cellulose was negative in the Ames mutagenicity assay [FMC Study Number I91-1189], and caused no <>/ExtGState<>/Font<>/ProcSet[/PDF/Text/ImageB/ImageC/ImageI] >>/MediaBox[ 0 0 612 792] /Contents 6 0 R/Group<>/Tabs/S>>
Generally, these can be classified into two broad groups: Standard grades, and Co-processed grades. l~5C
Cellulose microcrystalline for column chromatography. The UK Health & Safety Executive has set workplace exposure limits at 10 mg/m3 long-term (8 hr TWA) for total inhaled dust and 4 mg/m3 for respirable dust. METHOCEL cellulose ethers are water-soluble polymers derived from cellulose. BIOACCUMULATIVE POTENTIAL
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Product and Company Identification . However, with many different grades (standard and specialty) on offer, how do you select the correct material for your needs? However, consumption of large quantities of the material may have a laxative effect. Combines good flow and high compactibility. Microcrystalline cellulose is an exceptional material and one of the most widely used excipients in the pharmaceutical field. Explore our end markets, products, ingredients and essential solutions or get in touch with us about your order. 3t;zAXa[j.7ZX[GL9e,>6sVV`T6`#W stream
IFF has decades of experience controlling these naturally derived materials, which means you can count on consistent performance, every time. Microcrystalline Cellulose (MCC) MSDS 1. Microcrystalline Cellulose; Cellulose; Functions. The 'Substance identity' section is calculated from substance identification information from all ECHA databases. Earth Supplied Products LLC. It is made from purified partially depolymerised Alfa cellulose relatively free from both organic and inorganic contaminants. Low use levels of GRINDSTED Xanthan Gum are sufficient to provide desired viscosities and textures. A family of polysaccharide products that allow distinctive drug delivery solutions. Truly distinctive drug delivery solutions. Aquacoat sustained release coating is a pseudo latex aqueous dispersion of water insoluble polymers used for sustained and enteric coating applications. Examination of urine, blood and faecal levels of vitamin B 1 during microcrystalline cellulose ingestion showed no difference from control periods (Anonymous, 1966). Some substance identifiers may have been claimed confidential, or may . These co-processed products are designed to solve complex formulation problems, simplify manufacturing processes, and deliver significant cost savings. 102331. $4%&'()*56789:CDEFGHIJSTUVWXYZcdefghijstuvwxyz ? Carboxymethyl Cellulose Sodium N/A Nutrition & Biosciences www.pharma.dupont.com HO 00017 - 0 E L 02.2020 www.dupontnutritionandbiosciences.com . iq/iVO"5VI}dn.#q^(fJ),BN
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