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2022 Nov 1;43(6):555-558. doi: 10.2500/aap.2022.43.220058. Br J Dermatol. These types cannot cause cold sores or genital herpes. JAAD Case Rep 2018; 4: 800801. Pityriasis rosea is a rash that usually appears on the torso, upper arms, thighs or neck. government site. Considering the actual epidemiological context, we performed a real-time reverse transcriptase-polymerase chain reaction (RT-PCR) assay from nasal and pharyngeal swabs for coronavirus disease 2019 (COVID-19) to investigate the PR etiology. In some cases, central hyperpigmentation was identified. This article presents a case of PR in a 66-year-old black male 1 week after administration of the Pfizer-BioNTech COVID-19 vaccine. (2015) 2015:253154. doi: 10.1155/2015/253154, 14. It often presents with diffuse and confluent severely pruritic dusky-red erythematous lesions in the absence of herald patch (11). doi: 10.1159/000517971. Treatment may include various topical and oral drugs. doi: 10.1111/jdv.17498. Authors Jordan E Buckley 1 , Laura N Landis 2 , Ronald P Rapini 1 Affiliations 2022 by the American Academy of Dermatology, Inc. Epstein-Barr virus reactivation after COVID-19 vaccination in a young immunocompetent man: a case report. Khalili M, Abtahi-Naeini B, Rastegarnasab F, Afshar K. Clin Case Rep. 2022 Jul 19;10(7):e6096. 2021 Jul;85(1):46-55. doi: 10.1016/j.jaad.2021.03.092. Pityriasis rosea as a cutaneous manifestation of COVID-19 infection Pityriasis rosea as a cutaneous manifestation of COVID-19 infection Pityriasis rosea as a cutaneous manifestation of COVID-19 infection Pityriasis rosea as a cutaneous manifestation of COVID-19 infection J Eur Acad Dermatol Venereol. American Academy of Dermatology's National Library of Dermatologic Teaching Slides. 2022 Nov;36(11):1947-1968. doi: 10.1111/jdv.18294. Skin lesions appeared in a 49-year-old female 8 days after the first dose of the BNT162b2 mRNA vaccine and in a 53-year-old male 7 days after the second dose of the same . For instance, the rash sometimes appears only under the arms or on the flanks. Your skin may develop discolored patches (lesions) that look like scales or dry, crinkly paper. Treatment with topical 0.1% triamcinolone acetonide twice daily showed partial response after seven days. KL drafted the original manuscript. 2021 Oct;20(10):3080-3084. doi: 10.1111/jocd.14372. (2017) 9:7399. doi: 10.4081/dr.2017.7399, 17. To the best of our knowledge, there have been no reports of PR-like eruptions following inoculation with Oxford/AstraZeneca ChAdOx1 nCoV-19 (AZD1222) vaccine. Accessibility (d) Patient 2: Closeup of plaques, with the hyperpigmented centre and trailing scale. In conclusion, we have described the first case of PR-like eruption following ChAdOx1 nCoV-19 (Oxford/AstraZeneca) vaccination. J Eur Acad Dermatol Venereol 2020;34:e4367. 8 In some cases, antibodies against HHV6/7 as well as viral DNA in plasma and PBMCs were detected. 2021 Dec;108(6):317-318. doi: 10.12788/cutis.0411. government site. A virus may cause pityriasis rosea, but experts arent sure. Blood tests to check for causes of a rash that arent related to pityriasis rosea. In darker-skinned or Black people, the patches may be more raised (papular), and the centers of the patches may look like the tissue is dying (necrotic). The https:// ensures that you are connecting to the Among patients who received COVID-19 vaccines, PR-like eruptions have been reported following the first (n = 1) or second dose (n = 2) of BNT162b2 mRNA-based vaccines (3, 4). Please enable it to take advantage of the complete set of features! Pityriasis Rosea Associated With COVID-19 Vaccination: A Common Rash Following Administration of a Novel Vaccine. Use of this site constitutes acceptance of our Ehsani AH, Nasimi M, Bigdelo Z. Pityriasis rosea as a cutaneous manifestation of COVID-19 infection. Sriphojanart T, Khunkhet S, Suchonwanit P. A retrospective comparative study of the efficacy and safety of two regimens of diphenylcyclopropenone in the treatment of recalcitrant alopecia areata. 2022 Oct;123:58-69. doi: 10.1016/j.ijid.2022.06.037. (2021) p. e15040. We present the case of a female patient in whom the diagnosis of pityriasis rosea led to the investigation and diagnosis of the SARS-CoV-2 infection. I also had to stop working out and hiking for about a week, as Alexiades is right excessive perspiration worsened the itch. Bethesda, MD 20894, Web Policies You also wont have permanent scarring or other damage to your skin. An official website of the United States government. 2021 Sep;35(9):e546-e548. Figure 2. A more recent letter in the International Journal of Dermatology reported a "unique case of pityriasis rosea following administration of mRNA COVID-19 vaccine." Apply a moisturizer, calamine lotion or a nonprescription . The etiopathogenesis of PR is still unknown, but is frequently associated with episodes of upper respiratory tract infections. Get more info about other skin conditions: The Ultimate Guide to Skin Conditions for Black & Brown Folks, I Thought I Just Had Dry Skin, But It Was Actually Perioral Dermatitis, Everything You Should Know About Hidradenitis Suppurativa. 1 Several vaccines have been developed to fight against COVID19, to prevent the transmission among susceptible individuals and to decrease the morbidity Policy. All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Unable to load your collection due to an error, Unable to load your delegates due to an error. 2021 Jun 25;118(25):431. doi: 10.3238/arztebl.m2021.0257. You may be at risk of developing an allergic reaction on your skin. The evolution was unfavorable, with the spread of the lesions and the accentuation of the pruritus. Disclaimer. Get useful, helpful and relevant health + wellness information. (2020) 33:e13878. An official website of the United States government. Histopathologic examination revealed epidermal focal spongiosis, interface dermatitis with necrotic keratinocytes, perivascular lymphocytic infiltration, and few eosinophilic infiltrations in the superficial dermis (Figures 3B,C). If you have pityriasis rosea, the rash with go away without treatment. Unauthorized use of these marks is strictly prohibited. Advertising on our site helps support our mission. Skin lesions appeared in a 49-year-old female 8 days after the first dose of the BNT162b2 mRNA vaccine and in a 53-year-old male 7 days after the second dose of the same vaccine. Pityriasis rosea after administration of Pfizer-BioNTech COVID-19 vaccine. User Agreement and Privacy Policy and Cookie Statement and A spectrum of cutaneous reactions to SARs-CoV-2 (COVID-19) vaccines have been reported in the literature. The symptoms of pityriasis rosea usually develop in stages: Pityriasis rosea doesnt hurt. Allergy Asthma Proc. 2021;185(2):e34. Pityriasis Rosea Associated With COVID-19 Vaccination: A Common Rash Following Administration of a Novel Vaccine. . COVID-19 vaccines reactions, type I hypersensitivity reactions (such as urticaria, angioedema, and anaphylaxis), . Med. 2021 Aug;185(2):e34. 2022 Mar 15;10(3):624. doi: 10.3390/microorganisms10030624. Lastly, Hartman says PR can present differently in patients with darker skin: "The characteristic erythematous plaques may appear more hyperpigmented or violaceous in darker skin types. Cutaneous reactions reported after Moderna and Pfizer COVID-19 vaccination: A registry-based study of 414 cases. eCollection 2022. Pityriasis Rosea-like eruptions following COVID-19 mRNA-1273 vaccination: A case report and literature review. Epub 2021 Jul 21. Martn Enguix D, Salazar Nievas MDC, Martn Romero DT. While my particular flare-up itched a lot, that's not always the case. 2022 Jul 8;101(27):e29823. Careers. While annoyingly itchy, the rash does not cause any serious long-term side effects and is not contagious, unlike the diseases these vaccines protect against. Pityriasis rosea is a common condition that causes discolored patches on your skin. 2022 Jan;114:88-89. doi: 10.1016/j.ijid.2021.10.055. Here, we report the first case of PR-like eruption following ChAdOx1 nCoV-19 (Oxford/AstraZeneca) vaccination. sharing sensitive information, make sure youre on a federal NCI CPTC Antibody Characterization Program. Pityriasis rosea (PR)-like eruption is a rare cutaneous complication of immunization. Epub 2022 Oct 17. Dermatology. Bookshelf Influenza viruses and vaccines have triggered pityriasis rosea in some cases.". Br J Dermatol. Of the 30 cases found, none experienced severe adverse effects and the rash resolved in an average of 5.6 weeks. Clin Exp Dermatol 2010;35:3004. The Covid Symptom Study. Epub 2021 Aug 7. J Eur Acad Dermatol Venereol 2016; 30: 544-545. eCollection 2021. 9 , 10 These findings suggest that immuneinduced viral reactivation - rather than See this image and copyright information in PMC. Cureus. Careers. Epub 2022 May 31. 2021 Sep;35 (9):e546-e548. It's also what's known as a self-limiting rash, Hartman says, in that it can resolve itself on its own without treatment in about six to eight weeks. One week before the rash, respiratory tract infection symptomatology was observed by the patient. (A) Dermoscopic features: dotted and linear vessels forming a network on a yellowish background with some whitish peripheral scales (original magnification x20). and transmitted securely. (a) Pityriasis rosea (chest, flank, and axilla); (b) pityriasis rosea (back). It looked like one, and it certainly itched like one but then more came. Pityriasis rosea often occurs this way, but not always. Some rare cases can take up to three months. In a registry-based study, PR-like eruption was observed in only 12% of patients (14). National Library of Medicine The https:// ensures that you are connecting to the 2022 Mar 9;35(3):342-343. doi: 10.1080/08998280.2022.2044742. -, Neoh CY, Tan AW, Mohamed K, et al. Your symptoms dont improve after treatment. The patient developed papulovesicular lesions in the crease lines of the trunk and extremities, four days after inoculation with a recombinant coronavirus vaccine (Covishield, India). Drago F, Ciccarese G, Javor S, et al. This rash is thought to be caused by a virus. Disseminated erythematous-papulosquamous lesions, with right. Fortunately, PR-like eruption is responsive to topical corticosteroids without any systemic adverse effects. Pityriasis Rosea. The authors have no conflicts of interest to declare. 2022 May;11(2):222-225. doi: 10.7774/cevr.2022.11.2.222. (2016) 30:5445. Also, topical medication with dermatocorticosteroids and emollients was associated. Previously, PR has been reported in temporal association with various viral inoculations. Contact your healthcare provider as soon as you notice a rash. The authors have no conflicts of interests to disclose. Pityriasis rosea is also known as Christmas tree rash. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). Federal government websites often end in .gov or .mil. A variant called inverse pityriasis rosea can affect the skin on your neck, face, armpits (axillae) and groin, though it isnt common. 2022 Nov;36(11):1947-1968. doi: 10.1111/jdv.18294. -, Carballido Vzquez A.M., Morgado B. Pityriasis rosea-like eruption after Pfizer-BioNTech COVID-19 vaccination. However, if you scratch your patches, you may break your skin, leading to an infection that can cause pain. Table 1 summarizes all reported cases of PR-like eruption following COVID-19 vaccination. 6 Called a "herald patch,". Epub 2021 Nov 2. Various mild and benign cutaneous manifestations of the different forms of the COVID-19 vaccine have been documented. 2022 Aug;35(8):e15601. You may develop a raised, discolored, circular or oval-shaped patch that ranges from 1 to 6 centimeters (cm). Oily fish, such as mackerel, salmon or sardines. The good news is many of those who develop pityriasis rosea never get it again, says New York City-based dermatologist Hadley King. This reaction is self-limited and resolves in an average of 5.6 weeks. eCollection 2022 Jul. HHS Vulnerability Disclosure, Help It said blood spots under the skin might also be present, either as spots or dots or on larger areas. -, Cyrenne BM, Al-Mohammedi F, DeKoven JG, Alhusayen R. Pityriasis rosea-like eruptions following vaccination with BNT162b2 mRNA COVID-19 vaccine. Drug-induced PR-like eruption accounts for 2% of all cutaneous adverse drug reactions (10). Bethesda, MD 20894, Web Policies These findings were consistent with a diagnosis of PR-like eruption. Suchonwanit P, Leerunyakul K, Kositkuljorn C. Cutaneous manifestations in COVID-19: Lessons learned from current evidence. 2021;85(1):4655. -, Polack FP, Thomas SJ, Kitchin N et al. 8600 Rockville Pike The mechanisms behind these COVID-19-related symptoms remain unclear. Is there a prescription cream or ointment that you can prescribe? Epub 2022 Jan 31. If you need help purchasing a product directly from Allure, go to our FAQ. Once its gone, you likely wont develop it again. Pityriasis rosea-like eruption revealing COVID-19. Washrawirul C, Triwatcharikorn J, Phannajit J, Ullman M, Susantitaphong P, Rerknimitr P. J Eur Acad Dermatol Venereol. eCollection 2022 Feb. Kroumpouzos G, Paroikaki ME, Yumeen S, Bhargava S, Mylonakis E. Microorganisms. 2023 Cond Nast. (2021). Clinical manifestations and histopathologic findings of reported patients with pityriasis-rosea like eruptions following COVID-19 vaccination.